{"id":25096,"date":"2025-03-03T12:09:11","date_gmt":"2025-03-03T11:09:11","guid":{"rendered":"https:\/\/agora.xtec.cat\/inslacetania\/?p=25096"},"modified":"2025-03-03T12:09:17","modified_gmt":"2025-03-03T11:09:17","slug":"nou-mapa-de-lespliceosoma-un-pas-endavant-en-la-lluita-contra-el-cancer","status":"publish","type":"post","link":"https:\/\/agora.xtec.cat\/inslacetania\/revista\/nou-mapa-de-lespliceosoma-un-pas-endavant-en-la-lluita-contra-el-cancer\/","title":{"rendered":"Nou mapa de l\u2019Espliceosoma: un pas endavant en la lluita contra el c\u00e0ncer"},"content":{"rendered":"<p>Un equip d\u2019investigadors del Centre de Regulaci\u00f3 Gen\u00f2mica (CRG) de Barcelona ha aconseguit fer un aven\u00e7 hist\u00f2ric en la comprensi\u00f3 del funcionament cel\u00b7lular. Per primera vegada, s\u2019ha elaborat un mapa detallat de <strong>l\u2019espliceosoma<\/strong>, una m\u00e0quina cel\u00b7lular clau en el processament de l\u2019ADN.<\/p>\n<p><a href=\"https:\/\/cordis.europa.eu\/article\/id\/92543-elucidating-spliceosome-structure-and-function\/es\">L&#8217;espliceosoma<\/a> \u00e9s un complex de grans dimensions format per prote\u00efnes i ARN que catalitza l&#8217;eliminaci\u00f3 d&#8217;introns de l&#8217;ARN premissatger (preARNm) i l&#8217;empalmament d&#8217;exons codificants per produir ARNm madurs. En resum, processa l\u2019ARN missatger eliminant les parts innecess\u00e0ries (introns) i unint les \u00fatils (exons) per produir prote\u00efnes correctes.<\/p>\n<p>Segons els cient\u00edfics del CRG, el mapa detallat permet entendre millor com es produeix aquest error i podrien sorgir noves estrat\u00e8gies terap\u00e8utiques. \u201cAquest descobriment \u00e9s crucial per al disseny de futurs tractaments que puguin corregir les disfuncions de l\u2019espliceosoma i, per tant, prevenir o combatre determinats tipus de c\u00e0ncer\u201d, va dir el doctor Manuel Rodr\u00edguez, un dels investigadors principals de l\u2019estudi.<\/p>\n<p>L\u2019estudi, que va ser publicat a la revista <em>Nature<\/em>, tamb\u00e9 destaca la import\u00e0ncia de l\u2019espliceosoma en altres malalties gen\u00e8tiques i neurodegeneratives. En aquest sentit, els experts consideren que l\u2019avan\u00e7 podria tenir implicacions, no nom\u00e9s en oncologia, sin\u00f3 tamb\u00e9 en el tractament de patologies com l\u2019atr\u00f2fia muscular espinal o certes formes de distr\u00f2fia muscular.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Un equip d\u2019investigadors del Centre de Regulaci\u00f3 Gen\u00f2mica (CRG) de Barcelona ha aconseguit fer un aven\u00e7 hist\u00f2ric en la comprensi\u00f3 del funcionament cel\u00b7lular. Per primera vegada, s\u2019ha elaborat un mapa detallat de l\u2019espliceosoma, una m\u00e0quina cel\u00b7lular clau en el processament de l\u2019ADN. L&#8217;espliceosoma \u00e9s un complex de grans dimensions format per prote\u00efnes i ARN que [&hellip;]<\/p>\n","protected":false},"author":1331,"featured_media":25098,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[136,102],"tags":[],"class_list":["post-25096","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies","category-revista"],"post_mailing_queue_ids":[],"_links":{"self":[{"href":"https:\/\/agora.xtec.cat\/inslacetania\/wp-json\/wp\/v2\/posts\/25096","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/agora.xtec.cat\/inslacetania\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/agora.xtec.cat\/inslacetania\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/agora.xtec.cat\/inslacetania\/wp-json\/wp\/v2\/users\/1331"}],"replies":[{"embeddable":true,"href":"https:\/\/agora.xtec.cat\/inslacetania\/wp-json\/wp\/v2\/comments?post=25096"}],"version-history":[{"count":3,"href":"https:\/\/agora.xtec.cat\/inslacetania\/wp-json\/wp\/v2\/posts\/25096\/revisions"}],"predecessor-version":[{"id":25350,"href":"https:\/\/agora.xtec.cat\/inslacetania\/wp-json\/wp\/v2\/posts\/25096\/revisions\/25350"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/agora.xtec.cat\/inslacetania\/wp-json\/wp\/v2\/media\/25098"}],"wp:attachment":[{"href":"https:\/\/agora.xtec.cat\/inslacetania\/wp-json\/wp\/v2\/media?parent=25096"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/agora.xtec.cat\/inslacetania\/wp-json\/wp\/v2\/categories?post=25096"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/agora.xtec.cat\/inslacetania\/wp-json\/wp\/v2\/tags?post=25096"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}