El dimarts dia 2 de desembre, l’alumnat de Biologia de 1r i 2n de Batxillerat van assistir a una confer\u00e8ncia telem\u00e0tica impartida pel Dr. Francisco Barro, dins el programa de Tert\u00falies de Literatura Cient\u00edfica que organitza la UVIC.<\/p>\n
El Dr. Francisco Barro \u00e9s Doctor en Biologia, investigador del CSIC i responsable del grup de Gen\u00f2mica Funcional de l\u2019Instituto de Agricultura Sostenible (IAS). La seva recerca s\u2019ha dirigit en aconseguir blat apte per a cel\u00edacs, lliure del component del gluten que m\u00e9s immunogenicitat genera. El gluten \u00e9s una barreja complexa de prote\u00efnes presents als cereals, responsable d\u2019al\u00b7l\u00e8rgies i intoler\u00e0ncies que afecten el 12% de la poblaci\u00f3 mundial. Consta de gliadines (\u03b1, \u03b2, \u03d2, \u03c9, el p\u00e8ptid 33 mer \u00e9s un dels components de l\u2019 \u03b1-gliadina, \u00e9s molt resistent a la digesti\u00f3 i un dels principals p\u00e8ptids immunog\u00e8nics del gluten) i glutenines (donen l\u2019elasticitat a la farina)
\nEs pot emprar la t\u00e8cnica del RNAi (RNA d\u2019interfer\u00e8ncia) i la del CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats associat a endonucleasa Cas).
\nA trav\u00e9s de les dues eines biotecnol\u00f2giques s\u2019ha aconseguit blat sense 33-mer. Amb la primera s\u2019aconsegueix interferir en la s\u00edntesi de les gliadines (s\u2019interfereix en la traducci\u00f3 de la prote\u00efna, per degradaci\u00f3 de m-RNA). En la segona, es pot eliminar la seq\u00fc\u00e8ncia gen\u00e8tica que porta la informaci\u00f3 per a la 33-mer, a trav\u00e9s de RNA guia (sgRNA) associat a la nucleasa Cas.<\/p>\n
El blat sense gliadina aconseguit per la tecnologia CRISPR, a la Uni\u00f3 Europea \u00e9s considerat blat modificat gen\u00e8ticament, en canvi a Estats Units, en no tenir gens addicionals provinents d\u2019una altra esp\u00e8cie, no.<\/p>\n
Sigui quina sigi l’eina biotecnol\u00f2gica emprada, el blat sense gliadina permet obtenir farina que es pot treballar b\u00e9 i pa de qualitat ,tot i que t\u00e9 una mica menys de volum. <\/p>\n
Per assajos cl\u00ednics efectuats s\u2019ha constatat que les persones que han consumit pa sense gliadines presenten una microbiota que millora la permeabilitat intestinal, una disminuci\u00f3 dels p\u00e8ptids antig\u00e8nics i un descens dels bacteroides que provoquen inflamacions.<\/p>\n","protected":false},"excerpt":{"rendered":"
A trav\u00e9s d’eines biotecnol\u00f2giques -RNAi i CRISPR-Cas- s’ha aconseguit blat lliure del p\u00e8ptid m\u00e9s immunog\u00e8nic del gluten. El gluten \u00e9s el responsable de la celiaquia. Aconseguir blat sense gluten \u00e9s un aven\u00e7 que pot ajudar a molts cel\u00edacs.<\/p>\n","protected":false},"author":13,"featured_media":6622,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[8,1,29],"tags":[],"class_list":["post-6620","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-batxillerat","category-general","category-portada"],"post_mailing_queue_ids":[],"_links":{"self":[{"href":"https:\/\/agora.xtec.cat\/iesjaumecallis\/wp-json\/wp\/v2\/posts\/6620","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/agora.xtec.cat\/iesjaumecallis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/agora.xtec.cat\/iesjaumecallis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/agora.xtec.cat\/iesjaumecallis\/wp-json\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"https:\/\/agora.xtec.cat\/iesjaumecallis\/wp-json\/wp\/v2\/comments?post=6620"}],"version-history":[{"count":2,"href":"https:\/\/agora.xtec.cat\/iesjaumecallis\/wp-json\/wp\/v2\/posts\/6620\/revisions"}],"predecessor-version":[{"id":6623,"href":"https:\/\/agora.xtec.cat\/iesjaumecallis\/wp-json\/wp\/v2\/posts\/6620\/revisions\/6623"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/agora.xtec.cat\/iesjaumecallis\/wp-json\/wp\/v2\/media\/6622"}],"wp:attachment":[{"href":"https:\/\/agora.xtec.cat\/iesjaumecallis\/wp-json\/wp\/v2\/media?parent=6620"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/agora.xtec.cat\/iesjaumecallis\/wp-json\/wp\/v2\/categories?post=6620"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/agora.xtec.cat\/iesjaumecallis\/wp-json\/wp\/v2\/tags?post=6620"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}